Assessing the Impact of Mandibular Molar Root Length on Success in Supplemental Intraligamentary Injection for Irreversible Pulpitis

Introduction: This study investigates the influence of root length in mandibular molars with irreversible pulpitis on the success of supplemental intraligamentary injection following an inferior alveolar nerve (IAN) block. Various factors, including anatomical location, tooth type, and anesthetic solution, may affect supplemental anesthesia success. Materials and Methods: A total of 251 patients diagnosed with irreversible pulpitis in mandibular first or second molars underwent buccal infiltration anesthesia (4% articaine with 1:100,000 epinephrine) after IAN block injection (3% prilocaine and 0.03 IU/mL of felypressin). Fifty patients experiencing pain during access cavity preparation received supplemental intraligamentary injection (0.3 mL of 2% lidocaine with 1:80,000 epinephrine) at each mesial and distal line angle. The root length of treated teeth was recorded using an apex locator. Data analysis involved independent t-tests, Chi-square tests, and logistic regression. Results: Successful supplemental intraligamentary injection was observed in 21 (42%) out of 50 patients. No significant correlation was found between the mean length of mesiobuccal (P=0.61), mesiolingual (P=0.34), or distal (P=0.60) canals of mandibular molars and the injection's success. Logistic regression analysis, however, revealed a significant impact of mesiolingual canal length on the success rate [OR 0.09 (0.01-0.79), P=0.030]. Conclusion: The root length of mandibular first and second molars does not significantly affect the success of supplemental intraligamentary injection

The factors affecting job motivation of university employees and its relationship with health factors at workplace

Background: Job motivation of workforce is one of the most important issues that organizations face to perform their tasks and duties well and with confidence and maintain their effectiveness. Methods: The present study was applied research conducted by using a combination of library studies and Delphi technique. The sample size of the present study was 332 employees of Islamic Azad University of Khuzestan. They were selected using Cochran's formula. Two researcher-made questionnaires including job motivation questionnaire with 54 questions and health factors questionnaire with 30 questions were used to collect the data. The collected data were analyzed by SPSS-22, Lisrel, and Amos-22 Software. Results: The variable of factors related to job motivation consisted of 15 components. The variable of job motivation in general found that according to the scoring scale of Abbas Bazargan, this variable is at more than satisfactory level. The variable of health factors was at more than satisfactory level. There was significant association between job motivation with health factors (P<0.001). Relationship between job motivation and health factors showed that direct and significant relationship between job motivation with health factors. The value of path coefficient of impact of health factors on job motivation showed that the relationship between job motivation and health factors is significant. Conclusion: Job motivation is a multidimensional phenomenon that cannot be measured directly by one variable. One of the important tasks of organizations is finding the ways to create and strengthen motivation. Managers should consider motivating employees as one of the most important tasks

Selection of Efficient Inhibitors for Caspas-9 according to Structure-Based Pharmacophore Screening Strategy and Molecular Dynamics Simulations

Caspases are enzymes which are the main pathways for apoptosis. Any irregulation in their functions causes increase or decrease in cell death, which result in autoimmune disease or cancer, respectively. In this study, structure-based pharmacophore drug discovery method as a virtual screening was used to discover selective inhibitors for caspase-9. This enzyme is an initiator caspase that is the main pathway in Alzheimer’s disease. A pharmacophore model was developed by investigating essential interactions among the reported potent inhibitors employing a docking analysis methodology. Applying pharmacophore virtual screening, nine compounds from both National Cancer Institute (NCI), and ZINC databases were filtered as potent inhibitors of caspase-9. The efficiency of the discovered compounds was further investigated by docking studies.HIGHLIGHTS•Caspase-9 is an important enzyme for apoptosis and its activity is pivotal in cell death.•A computational design of small molecular inhibitors for caspase-9 performed by structure-based pharmacophore model.•9 compounds from both National Cancer Institute (NCI) and ZINC databases were discovered as potent inhibitors

Consequences of Opioid Abuse and their Treatments in Persian Medicine: A Review Study

Background: Drug addiction is a major health problem for modern human communities. The earliest historicalevidence of opium use can be found in the writings of Theophrastus in the 3rd century BC. Since then, opiumuse and abuse has spread to all corners of the world, specifically the Eastern countries. This study aimed toinvestigate the consequences of opium use and their treatments according to Persian medicine.Methods: In this narrative review, primary sources of Persian medicine and modern medicine databases ofPubMed, Google Scholar, PsycINFO, the American Academy of Medical Sciences, and the United NationsOffice on Drugs and Crime (UNODC) were searched with relevant keywords.Findings: In Persian medicine, the Persian equivalent of the word “Opium” is “Afioon”, which refers to thesap of “Khashkhaash” or Papaver somniferum, traditionally used as a recreational drug as well as a sedative.Opioid use can cause social and psychological anxiety, muscle and tissue degradation, irritability, stomachweakness, loss of skin softness, and change in facial features.Conclusion: Opium addiction is generally harmful to the body’s faculties. The repeated use of opium,disregarding circumstances and dosage of use and without the simultaneous use of its modifiers, can harmthe entire body and even lead to fatality

Alcohol Abuse, Consequences and Treatments from the Perspective of Traditional Iranian Medicine: A Review Study

Background: Alcohol use has always been prevalent in human societies, but in many Muslim-majority countries, including Iran, national laws prohibit the consumption of this substance. Methods: In this study, reference books on traditional Iranian medicine and electronic documents from Google Scholar, PubMed, and Scopus were searched for entries about the consequences and treatments of alcohol abuse. Findings: Seminal books of traditional Iranian medicine refer to alcoholic beverages using two terms, namely, “khamr” and “sharâb” (wine). These sources indicate that the temperament of “sharâb” is generally warm but may vary depending on color, taste, concentration, and age. Traditional Iranian medicine views wine as a cause of multiple adverse effects on health. Conclusion: Traditional Iranian medicine advocates the beliefs that no level of alcohol use is beneficial for health and that physicians should advise against alcohol consumption even in small amounts. Scholars of indigenous medical practices have long been opposed to the adoption of wine as a remedy or otherwise, as they believe that the benefits of alcohol are dwarfed by its harmful effects

Mood, Dimensional Personality, and Suicidality in a Longitudinal Sample of Patients with Bipolar Disorder and Controls

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/151828/1/sltb12529_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/151828/2/sltb12529.pd

Numerical Investigation of the Impact of Inlet Channel Numbers on the Flow Pattern, Performance, and Erosion of Gas-particle Cyclone

The effect of adding extra inlet channels on the operation of the Stairmand Cyclone has been investigated numerically. The Reynolds stress model (RSM) and Eulerian-Lagrangian method were used to investigate the complex turbulent flow and cyclone performance. The impacts of one-way coupling and two-way coupling models on the cyclone efficiency and the calculation of cut-off size diameter were examined. The results showed that a rise in channel number increases the tangential velocity and extends the Rankine vortex region. Moreover, in the four-inlet cyclone, the direction of flow changes unlike the one-inlet and two-inlet cyclones, and it behaves like a jet flow. According to the results, the collection efficiency and cut-off size diameter of the four-inlet cyclone are respectively about 10.78% higher and 35% lower than those of one-inlet configuration. Therefore, the performance of four-inlet cyclone is the highest among the three investigated configurations due to high tangential and axial velocities. A cyclone with more inlets has a more symmetrical flow pattern. Consequently, the four-inlet cyclone has the lowest flux of erosion among the others. The results of cyclone performance reveal a slight difference between one-way coupling and two-way coupling models

The Association of Serum Vitamin D Levels and Short Term and 6-month Outcomes among Patients with Acute Coronary Syndrome

Introduction: vitamin D affects the function of most of the cells in the body, including myocytes and endothelial cells, and also affects platelet function. This study aims to evaluate the relation between vitamin D deficiency and in-hospital and 6-month outcomes of patients with the acute coronary syndrome.Methods: This was a prospective cohort study of patients admitted to Mousavi hospital with the diagnosis of acute coronary syndrome. A venous blood sample obtained from patients at the time of admission and 25-hydroxyvitamin D, lipid profile, and hs-troponin-I levels were measured. After coronary angiography, the severity of the coronary artery stenosis was calculated by the syntax score. Patients also evaluated in-hospital outcomes and even followed up for 6-month results.Results: Totally, 204 patients were included in the study. The mean ± SD of age was 60 ± 11.6-year-old. The overall vitamin D deficiency was 80.9%. There was no association between vitamin D deficiency and in-hospital and 6-month mortality in patients with acute coronary syndrome (P = 0.824). There was a direct and statistically significant association between vitamin D levels and HDL cholesterol (P = 0.011). Twenty-eight percent of patients with negative hs-troponin-I and 14% with positive hs-troponin-I had normal vitamin D levels, which was statistically significant (P = 0.045).Conclusion: This study does not demonstrate an association between vitamin D levels and in-hospital and 6-month outcomes in patients with the acute coronary syndrome

Salivary melatonin onset in youth at familial risk for bipolar disorder

Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR). Adolescent participants (n = 12) were a mean age 14 ± 2.3 years and included 8 females and 4 males. Saliva samples were collected under standardized condition light (red light) and following a 200 lux light exposure over two consecutive nights in a sleep laboratory. Red Light Melatonin onset (RLMO) was defined as saliva melatonin level exceeding the mean of the first 3 readings plus 2 standard deviations. Polysomnography was also completed during each night. HR youth, relative to LR, experienced a significantly earlier melatonin onset following 200 lux light exposure. Polysomnography revealed that LR youth, relative to HR, spent significantly more time in combined stages 3 and 4 (deep sleep) following red light exposure. Additionally, regardless of the group status (HR or LR), there was no significant difference in Red Light Melatonin Onset recorded at home or in the laboratory, implying its feasibility and reliability

Identification of non‐reported bupropion metabolites in human plasma

Bupropion and its three active metabolites exhibit clinical efficacy in the treatment of major depression, seasonal depression and smoking cessation. The pharmacokinetics of bupropion in humans is highly variable. It is not known if there are any non‐reported metabolites formed in humans in addition to the three known active metabolites. This paper reports newly identified and non‐reported metabolites of bupropion in human plasma samples. Human subjects were dosed with a single oral dose of 75 mg of an immediate release bupropion HCl tablet. Plasma samples were collected and analysed by LC–MS/MS at 0, 6 and 24 h. Two non‐reported metabolites (M1 and M3) were identified with mass‐to‐charge (m/z) ratios of 276 (M1, hydration of bupropion) and 258 (M3, hydroxylation of threo/erythrohydrobupropion) from human plasma in addition to the known hydroxybupropion, threo/erythrohydrobupropion and the glucuronidation products of the major metabolites (M2 and M4–M7). These new metabolites may provide new insight and broaden the understanding of bupropion’s variability in clinical pharmacokinetics. © 2016 The Authors Biopharmaceutics & Drug Disposition Published by John Wiley & Sons Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134787/1/bdd2046_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/134787/2/bdd2046.pd